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Ketamine in a Holistic, Trauma-Informed Model of Care

For therapists used to traditional psychotherapy, Ketamine-Assisted Psychotherapy (KAP) can feel like a big shift. However, when placed within a trauma-informed, collaborative, and evidence-based model, ketamine does not replace therapy—it enhances it.

In fact, research shows ketamine can bring rapid relief, sometimes within hours or days. It is especially effective for treatment-resistant depression, suicidality, and PTSD. Unlike SSRIs or SNRIs, which often take weeks and help only part of the population, ketamine works differently. Specifically, it activates glutamatergic signaling, boosts neuroplasticity, and raises brain-derived neurotrophic factor (BDNF). As a result, clients gain more capacity for emotional processing, integration, and change.

When combined with psychotherapy, ketamine offers even greater benefits. Clients can:

  • Reach core material even if avoidance or numbness is present
  • Loosen rigid defenses and fear-based responses
  • Feel safe in a supportive therapeutic space
  • Engage their “inner healer,” a concept rooted in trauma-informed and somatic work

Importantly, KAP is not a quick fix. Instead, it works best within a preparation–dosing–integration model, where therapists guide reflection, meaning-making, and self-awareness.

Moreover, this approach is not fringe. Researchers at Yale, Johns Hopkins, MAPS, and the VA actively study and apply KAP. Therefore, it is increasingly recognized as a valid intervention in psychiatry, psychology, and trauma therapy.

At Stella Luna, we now offer KAP within our trauma-informed framework. Here, we place client readiness, ethical responsibility, and clinical discernment at the heart of this healing process.